Welcome to Computational Life Science laboratory, Yokohama City University, Japan!

Recent News

  • 【Research】”Mandibulofacial dysostosis with alopecia results from gain-of-ETAR function via allosteric effects on ligand binding” has been published in Journal of Clinical Investigation! [2023/1/13]

  • 【Research】”Structure of SARS-CoV-2 membrane protein essential for virus assembly” has been published in Nature communications! [2023/1/11]

  • 【Research】By combining AI and simulation, we have succeeded in the automated design and synthesis of novel organic fluorescent molecules! Published in Science Advances!

  • 【Research】We have developed a machine learning-based technology that evaluates 3D structures of proteins for structural biology. Published in Scientific Reports!


Our laboratory combines physicochemical molecular simulations and bioinformatics using super computers to conduct theoretical research on the three-dimensional structure and function of proteins, nucleic acids (DNA and RNA), and other biological macromolecules. We also use informatics methods such as machine learning and image processing to promote drug discovery and structural biology, as well as to broadly analyze biological and biological phenomena.